Will Mystro affect my acceptance rating?

Mystro automates your normal tasks and behavior. So if you choose to IGNORE a request rather than manually accept it, your acceptance rating will be affected just as it would if you were not using Mystro. Also,

Mystro displays a TRIP IGNORE pop-up when a trip is being ignored, so you always have the option to override Mystro and accept the trip to preserve acceptance rates. You are always in control.

Not to worry, because due to new laws, you can no longer be deactivated for low acceptance ratings. More info here: http://therideshareguy.com/how-to-take-advantage-of-ubers-new-acceptance-rate-policy

In addition, Mystro actually makes you more money used to manage both Uber and Lyft, so if you are worried about maintaining high acceptance rates for the purposes of bonuses, you'll still come out on top. See out study on the Mystro website.